STAT3 and glioblastoma: The anticancer effects of this natrual drug for the treatment of glioblastoma may occur mainly through the regulation of PI3K/Akt/mTOR signaling pathways, IL-6/STAT3 signaling pathways, modulation of apoptosis-related proteins, alteration of intracellular pH (pHi), and MMP-2/9 and fibronectin expressions [106] (Figure 2).