There are numerous studies in which it has been shown that curcumin inhibits STAT3 through induction of ROS or RANK gene activity in glioblastoma cells, or by suppressing JAK1, 2/STAT3 phosphorylation through downregulation of MMP-9, c-Myc, Ki-67, and Snail, suppressing cell proliferation, migration, and invasion by inducing G2/M cell cycle arrest [52–56] (Table 1). This evidence concerns the gene MMP9 and glioblastoma.