A study by Lamy et al. on olive oil compounds and their effect on glioblastoma cells has revealed that four compounds contained in extra virgin olive oil including hydroxytyrosol (HT), oleuropein (OL), oleic acid (OA), and tyrosol (Tyr) can inhibit tumor necrosis factor-α- (TNF-α-) induced expression of cyclooxygenase-2 (COX-2) in a U-87 MG cell line model as a human glioblastoma cell. This evidence concerns the gene TNF and glioblastoma.