In order to investigate the molecular mechanism of garcinol's action on pancreatic cancer cells, signaling molecules involved in apoptosis (X-IAP, cIAP, caspase 3/9, and PARP cleavage) were targeted, as well as NF-κB, VEGF, IL-8, and PGE2, which involve in chemoresistance in pancreatic tumors. This evidence concerns the gene VEGFA and pancreatic neoplasm.