Quercetin has the ability to impact apoptosis and arrest phase G1 cell cycle in tumor cells, through its interaction with cell cycle regulators, including cyclin-dependent kinase- (CDK-) 4 and cyclin D1, activating p53, cytochrome c release, and also inducing caspase 9 and caspase 3 release [109]. Here, TP53 is linked to neoplasm.