SHANK2 and Anxiety: The male–female difference in the reversal learning and anticipatory eye closure responses in Shank2-KO mice is intriguing in light of previous reports that male and female Shank2-KO mice display similar NMDAR hyperfunction and behavioral deficits in social, repetitive behavioral, locomotor, and anxiety-like domains as well as similar pharmacological rescue profiles of these deficits [60, 67].