Normalizing the NMDAR hypofunction in Shank2-KO mice by direct DCS-dependent NMDAR activation or by indirect NMDAR activation (through the zinc chelator, clioquinol, or early postnatal memantine treatment) rescues mainly social deficits but not other behavioral deficits, including hyperactivity, repetitive behaviors, and anxiety-related behaviors [60, 67, 71, 113]. Here, SHANK2 is linked to Anxiety.