It has also been reported that ccRCC lipid droplets rely on the lipid coat protein PLIN2 and that suppression of lipid droplets by inhibiting PLIN2 results in susceptibility to inducers of ER stress [14], implying a similar result may occur after reducing lipid droplets through ACSL3 inhibition. Here, ACSL3 is linked to nonpapillary renal cell carcinoma.