DNM1L and metastatic malignant neoplasm: Zhao et al. reported that the mitochondrial fission-related protein Drp1 is upregulated significantly in invasive breast cancer and during metastasis to lymph nodes and upregulated to a greater degree in metastatic breast carcinoma than in non-metastatic cancer; moreover, the fragmented mitochondrial content was positively related to the expression of Drp1 [60].