DNM1L and breast carcinoma: In addition, hypoxia-stimulated mitochondrial fission and cell migration were considerably reduced in MDA-MB-231 cells when Drp1-dependent mitochondrial fission was inhibited by Mdivi1 or Drp1 knockdown, which confirmed the regulation of Drp1-mediated mitochondrial fission in hypoxia-induced breast cancer metastasis [62].