Furthermore, they found that BNIP3, which plays a key role in mitochondrial autophagy, was also upregulated in breast cancer cells and that Drp1 inhibition significantly suppressed mitochondrial autophagy and decrease the viability of breast cancer cells, which revealed that Drp1 plays an essential role in regulating breast cancer cell survival via manipulating mitophagy. The gene discussed is DNM1L; the disease is breast carcinoma.