Mechanistically, GBP2 targets Drp1 and limits Drp1 translocation into mitochondria, thereby suppressing Drp1-dependent mitochondrial fission and breast cancer cell invasion, which suggests that GBP2 could be a potential therapeutic target for preventing breast cancer spread by inhibiting Drp1-dependent mitochondrial fission [32]. The gene discussed is GBP2; the disease is breast carcinoma.