INS and Insulin resistance: Consistent with our study, in the study of Thota et al. [29] no significant improvement in glycemic control parameters such as FPG and HbA1c was found after supplementation with curcumin (180 mg/day) for 12 weeks among subjects with T2DM; however, curcumin significantly improved insulin and homeostatic model assessment for insulin resistance (HOMA-IR).