In the adjusted model, not using ART was associated with an increased rate of severe COVID-19 infection (aRR = 3.15, 95% CI 1.616.19), as was a recent absolute CD4 count of less than 200 cells/mm3 (aRR = 2.15, 95% CI 1.12–4.14) and having an opportunistic infection or any comorbidity (aRR = 3.21, 95% CI 1.64–6.27 and aRR = 3.65, 96% CI 1.83–7.28). This evidence concerns the gene CD4 and Opportunistic infection.