According to the univariate analysis, thyroid cancer patients with elevated CREB3L1 expression (hazard ratio [HR] = 4.831, 95% confidence interval [CI]: 1.754–13.3, P = 0.00231) were more likely to die than those with lowered CREB3L1 expression (Table 3). The gene discussed is CREB3L1; the disease is thyroid gland carcinoma.