Moreover, SIRT3, an important regulator of mitochondrial antioxidant defense mechanism, scavenged mitoROS by stimulating deacetylation of superoxide dismutase 2, thus improving mitochondrial oxidative stress damage including essential hypertension, cardiac fibrosis, and diabetic cardiomyopathy [72–74]. The gene discussed is SOD2; the disease is diabetic cardiomyopathy.