While, the fat-specific omentin1 overexpression markedly increased the expression of Mfn2 and L-OPA1/S-OPA1 and decreased the level of p-Drp1(Ser616)/Drp1, which maintained mitochondrial dynamical homeostasis of myocardium in HF mice (Fig. 2E–G). Here, MFN2 is linked to hydrops fetalis.