ITLN1 and atherosclerosis: Preclinical studies demonstrated that omentin prevented the activation and senescence of vascular endothelial cells [33], diminished the calcification and proliferation of vascular smooth muscle cells [34], curbed macrophage infiltration and foam cell formation [35], and maintained cardiomyocyte function to promote cardiovascular health by improving cardiac vasorelaxation and preventing atherosclerosis [36, 37].