HK1 expression was clearly detected in orthotopic xenografts derived from HK1 knockdown Hepa1-6 cells in Hk1f/f mice but not in Hki1f/f;Gfap-Cre mice (Extended Data Fig. 4h), suggesting that the HK1 protein in tumor cells is likely transferred from HSCs in mice. Here, GFAP is linked to neoplasm.