HK1 and Hepatic fibrosis: Although it is well accepted that HK2 is an effective target for the suppression of HK1-negative and HK2-positive (HK1−HK2+) tumors from a wide variety of tissue origins44,50, our study suggests that combined inhibition of HK2 and secretion of lEV HK1 from HSCs may be a therapeutic strategy for HCC that develops from hepatic fibrosis.