HK1 and hepatocellular carcinoma: To verify the transfer of HK1 from HSCs, as well as the absence of de novo expression of HK1 in HCC cells in vivo, we used HK1 knockdown Hepa1-6 cells (Extended Data Fig. 4f) to establish orthotopic xenografts in Hk1f/f and Hk1f/f;Gfap-Cre mice.