ANGPTL7 and glaucoma: While a possibility, it is unlikely that the effect on IOP and glaucoma is due to MTOR, as: (i) the variants are predicted to be protein-altering in ANGPTL7 whereas there is no obvious predicted functional effect on MTOR; (ii) we show data suggesting that the variants have a functional impact on ANGPTL7; and (iii) we show mouse data that establish a role for ANGPTL7 in IOP regulation.