Instead, we posit an independent contribution of ANGPTL7 to IOP homeostasis based on the following: (1) The persistent association with reduced IOPcc suggests that there is IOP reduction even after controlling for corneal properties; (2) Angptl7 KO mice eyes show reduced basal IOP without evidence of corneal thinning or other corneal abnormalities; and (3) the association of ANGPTL7 variants with glaucoma protection is a result we would not expect if the reduction of IOP was purely due to ANGPTL7’s effect on corneal anatomy37. The gene discussed is ANGPTL7; the disease is glaucoma.