Schizophrenia patients with a pro-inflammatory signature exhibited possible alterations in the brain vasculature and BBB permeability more consistently than the general schizophrenia population (discussed in [7]), reflected by altered expression of structural and functional brain endothelial cells marker genes, such as ICAM1, CDH5, OCLN, and ABCG2 [4, 124]. This evidence concerns the gene CDH5 and schizophrenia.