COMT and Anxiety: For example, Tbx1 mutant mice have impairments in working memory, social behaviors, and anxiety-like behaviors that are consistent with human 22q11DS [152, 153], whereas Comt mutant mice showed either no effect on prepulse inhibition (PPI), social behaviors, and anxiety-like behaviors, or effects on working memory inconsistent with human 22q11DS [143, 146–149].