Shirato et al. showed that Asparagus officinalis stem standardized extract (EAS) attenuates SARS-CoV-2 spike protein S1 subunit (S1)-induced IL-6 and IL-1β production by suppressing p44/42 MAPK and AKT signaling in murine primary macrophages, suggesting that EAS may be beneficial in controlling excessive inflammation in COVID-19 patients [202]. Here, AKT1 is linked to COVID-19.