The FACS analysis of tumor mass revealed that while tumor-infiltrating T-cell populations, including CD3+, CD3+/CD4+, CD3+/CD8+ cells were significantly lower upon MLN4924 treatment, the combination with MEK inhibitor or anti-PD-L1 antibody restored the cytotoxic T-cell population (Fig. 6F–H). Here, CD4 is linked to neoplasm.