We then focused on H358 lung cancer cells and BxPC3 pancreatic cancer cells with PD-L1 at relatively low basal levels and inducible by MLN4924, and found MLN4924 increased PD-L1 expression at both protein and mRNA levels in dose- and time-dependent manners (Fig. 1A–D). Here, CD274 is linked to familial pancreatic carcinoma.