In epilepsy studies, developmental Cre-loxP recombination strategy (Orban et al., 1992) has contributed to the identification of many pathogenic mechanisms of genetic epilepsy (Boillot et al., 2014; Soh et al., 2014; Makinson et al., 2017; Klofas et al., 2020; Ishida et al., 2022), and some of these studies have suggested that hyperexcitation of Emx1-Cre+ forebrain excitatory neurons contribute to premature mortality in epilepsy (Sudden unexpected death in epilepsy SUDEP; Boillot et al., 2014; Soh et al., 2014; Bunton-Stasyshyn et al., 2019; Klofas et al., 2020; Ishida et al., 2022). Here, EMX1 is linked to epilepsy.