While activation of noncanonical inflammasomes requiring Caspase-4/5 in human epithelial cells is a hallmark of Salmonella infection, prior reports have found in murine intestinal epithelial cells, Caspase-1 together with Caspase-11, protect the epithelial monolayer [6], again highlighting differences in inflammasome engagement between human and murine intestinal cells. The gene discussed is CASP1; the disease is Salmonella Infections.