This association with oncogenesis with a role in control of HSCs (Hematopoietic Stem Cells) [21], LSCs (Leukemic Stem Cells) [22–25] and in iNSCs (immortalized Neural Stem Cells) [26–28] as well as in mesenchymal differentiation [29–34], involves ZNF521 in the control of the Stem Cells (SCs) compartment and in Cancer Stem Cells (CSCs). The gene discussed is ZNF521; the disease is cancer.