In particular, Cluster #42 for cv-score of 0.7 is a subpopulation of mature neutrophils (defined as CD66ace+CD66b+) whose levels of expression for CXCR1, CD15, CXCR2, IgA, CD66ace, CD66b, CD10, CD45RO, CD24 and CD16 best distinguishes between Lupus patients and Healthy donors (Fig 6D and 6E). This evidence concerns the gene CXCR2 and systemic lupus erythematosus.