In addition to the lack of EBNA2 and EBNA3A/B/C expression in EBV-infected epithelial cells, epithelial cells do not express the B-cell receptor (BCR), and we previously found that enhanced BCR activity is a major contributor to the increased lytic EBV infection that occurs in B cells with type 2 EBV infection [27,29]. Here, BCR is linked to Epstein-Barr virus infection.