SFRP4 and occult macular dystrophy: cytoHubba tool identified 14 hub genes (with a score ≥1) from this predicted network which includes, POSTN, COMP, COL11A1, MMP13, COL10A1, OMD, OGN, SFRP4, SFRP2, THBS4, CTHRC1, FAP, ADAMTS16 and FNDC1 (Fig 4I).