SPP1 and cancer: Oncomine analysis of core matrisome genes in the lung, gastric, ovarian and colon cancers show that a signature of 9 genes Collagen type XI alpha 1 chain (COL11A1), Secreted phosphoprotein 1 (SPP1), Microfibrillar associated protein 2 (MFAP2), Collagen type X alpha 1 chain (COL10A1), Biglycan (BGN), Cartilage oligomeric matrix protein (COMP), Agrin (AGRN) and Matrix remodelling associated 5 (MXRA5) is associated with poor survival and is involved in regulating cancer hallmarks such as epithelial to mesenchymal transition (EMT), and angiogenesis [15].