CTHRC1 and neoplasm: Query and Gene Ontology-based networks when compared identified Collagen type III alpha chain 1 (COL3A1) and receptor tyrosine kinase like receptor 2 (ROR2) as two genes that were conserved among these networks and could hence be involved in regulating CTHRC1 and its hub gene-mediated regulation of the tumour matrisome (Fig 7A–7E –labelled with the red circle).