Thus, in identifying CTHRC1 and the network of genes it works with across cancers, this study not only helps reveal the possible role POSTN, MMP13, SFRP4, FNDC1 and ADAMTS16 could have in regulating the impact of the matrisome in cancers but also highlights the role such a network could have in sustaining the same. Here, ADAMTS16 is linked to cancer.