Based on the significant effect they have on survival, tumour grade, correlation and co-occurrence analysis, we identified five genes, POSTN, MMP13, SFRP4, ADAMTS16 and FNDC1 as the most likely mediators of CTHRC1 dependent function in cancers (Fig 5E–represented in the Venn diagram). This evidence concerns the gene CTHRC1 and neoplasm.