IGFBP4 and cancer: Matrisome proteins like Insulin like growth factor binding protein 3, 4, 5 (IGFBP3, IGFBP4, IGFBP5), Cellular Communication Network factor (CCN) family, Thrombospondin2 (THBS2), Tenascin N (TNN) and Von Willebrand factor A 9 (VWA9) are detected primarily in cancer tissues [10] while Lysyl oxidase like 2 (LOXL2) [11], Cartilage oligomeric matrix protein (COMP), Periostin (POSTN) [12], Tenascin N (TNC) [13], Tenascin X (TNX) [13] and Fibronectin (FN) (EIIIA and EIIIB variant) [14] have been reported to be upregulated in cancers.