Further, network analysis reveals CTHRC1 could work with matrisome genes Periostin (POSTN), Matrix metalloproteinase 13 (MMP13), Secreted frizzled related protein 4 (SFRP4), Fibronectin type III domain containing 1 (FNDC1) and ADAM metallopeptidase with thrombospondin type 1 motif (ADAMTS16) in regulating the impact ECM has on cancers. This evidence concerns the gene SFRP4 and cancer.