cytoHubba tool identified 14 hub genes (with a score ≥1) from this predicted network which includes, POSTN, COMP, COL11A1, MMP13, COL10A1, OMD, OGN, SFRP4, SFRP2, THBS4, CTHRC1, FAP, ADAMTS16 and FNDC1 (Fig 4I). Here, COMP is linked to occult macular dystrophy.