The follow-up data for inpatient hospitalization of participants in the UK Biobank are updated periodically; therefore, the number of cirrhosis cases in the current analysis has more than doubled to approximately 4000 (3125 incident cases and 908 prevalent cases [Figure 1]) compared with previous studies of cirrhosis in this population.26,27 In addition, PNPLA3 I148M variant testing is now available. This evidence concerns the gene PNPLA3 and Cirrhosis.