The supramultiplicative interactive associations between the PNPLA3 I148M variant, obesity, and alcohol intake persisted across sensitivity analyses, which included stratification by sex (eTable 5 in the Supplement), were restricted to individuals at risk for steatosis (eTable 6 in the Supplement), and used a different criteria of alcohol intake (eTable 7 in the Supplement) and BMI (eTable 8 in the Supplement). Here, PNPLA3 is linked to obesity disorder.