In addition, low DDB2 expression was found in colon cancer of the T3-T4 stage and infiltrative growth type, similar to the tendency of decreased DDB2 expression in high-grade colon cancer found by Roy et al.[68] Survival analysis showed that high DDB2 expression was associated with good survival in colorectal cancer patients (adjusted HR 0.20, 95% CI 0.06–0.72, P = 0.014) and female colorectal cancer patients (adjusted HR 0.27, 95% CI 0.08–0.92, P = 0.036) [67]. This evidence concerns the gene DDB2 and colorectal cancer.