DDB2 and neoplasm: Alekseev et al. studied the transgenic mouse line K14-DDB2 (mice that ectopically express mouse DDB2 in their epidermal cells) and found that a high expression of DDB2 improved the repair of photodamage products in skin fibroblasts, delaying and reducing the occurrence of skin squamous cell carcinoma, and increased tumor-free survival [20].