In contrast, the knockout of PAQR3 (progestin and adipoQ 3) rescued the effects of DDB2 deletion on cell proliferation and migration.[73] As a newly discovered tumor suppressor, the function of PAQR3 is mainly due to its negative modulatory roles in Raf/MEK/ERK signaling pathway [74]. This evidence concerns the gene PAQR3 and neoplasm.