Although recruitment signals were not investigated in the study, several skin chemokines are essential for the early recruitment of neutrophils to the site of infection, including CXCL2 (MIP-2) produced by monocyte/macrophages, CXCL1 produced by keratinocytes, and lipopolysaccharide-induced LIX (CXCL5) (45, 46). The gene discussed is CXCL5; the disease is infection.