IL1B and insomnia: Further, we found that amino acids, including Valyl-Arginine, Phe-Phe, Phe-Trp, Ala-Trp-Arg-Lys, and immune factor, IL-1β, could mediate the relationship between species belonging to Prevotella and insomnia, indicating that Prevotella may affect sleep by regulating amino acid metabolism and promote inflammatory.