AKT1 and cancer: Several reports support our findings demonstrating that genotoxic stress regulates mTORC1, and that blockage of the Akt-mTORC1-S6K1 axis sensitizes cancer cells and tumors to radiation or chemotherapy (Braunstein et al., 2009; Alexander et al., 2010; Albert et al., 2006; Shen et al., 2013).