Interestingly, although PYCR1-deficiency, which in humans causes cutis laxa, causes cell death in the mouse central nervous system and in Xenopus and zebrafish skin (Reversade et al., 2009; Kuo et al., 2016; Escande-Beillard et al., 2020), Pycr1/2-deficient kidneys did not show increased apoptosis. This evidence concerns the gene PYCR1 and cutis laxa.