To determine whether AM DCN expression is required for ECP-mediated attenuation of BOS, we first replaced donor allograft AMs with DCNΔ/Δ or DCNfl/fl AMs by administering clodronate liposomes into the trachea of donor lung 3T-FVB mice 1 day prior to transplantation into respective DCNΔ/Δ or DCNfl/fl recipients (Figure 3A). This evidence concerns the gene DCN and Buschke-Ollendorff syndrome.