Finally, among APOE4 allele carriers, the mean rate of atrophy was greater for those who were HSV‐1 seronegative (7.595 mL per year (95%CI: 4.800 to 10.389; p < 0.001)) compared to those who were seropositive (3.735 mL per year (95% CI: 1.626 to 5.845, p < 0.001)); difference in mean atrophy rate: −3.860 mL per year, 95%CI: −7.329 to −0.391; p = 0.029). The gene discussed is APOE; the disease is Atrophy.