AKT1 and familial pancreatic carcinoma: To compare the effects of MIR143#12 on cell growth with the targeting of single genes, we silenced key genes in the KRAS signaling network, such as KRAS, AKT, and ERKs, using their corresponding small interfering RNA (siRNA) in colorectal and pancreatic cancer cell lines harboring various types of KRAS-related mutations.