Previous studies have reported that several lncRNAs bound to and inhibited the function of MIR143 in a number of cancer types, including colon cancer.25, 26, 27, 28 Expression of lncRNAs sponging MIR143 was more frequent in cancer than in normal tissue.25, 26, 27, 28 Therefore, the expression of these lncRNAs may contribute to the ineffectiveness of MIR143 against cancer cells. The gene discussed is MIR143; the disease is colonic neoplasm.