We recently demonstrated that chemically modified (CM) MIR143#12 significantly inhibited cancer cell growth by targeting KRAS, Son of sevenless homolog 1 (SOS1), AKT, and extracellular signal-regulated kinase (ERK) in colorectal cancer,15 bladder cancer,16 gastric cancer,17 and rhabdomyosarcoma cells.18 The gene discussed is SOS1; the disease is colorectal cancer.