Cardiovascular disease (ECG-report, hypertension, MI < 6 months, heart failure <30 days, chronic heart disease, Previous cardiac surgery or PCI, peripheral vasculopathy), cerebrovascular disease, respiratory disease (chronic lung diseases, respiratory failure), smoke, renal disease (acute/chronic), diabetes, liver disease (acute/chronic), solid tumor (localized/metastatic) leukemia, lymphoma, AIDS, drugs (oral anticoagulants, immunosuppressants or steroids, oral hypoglycemic agents or insulin), peptic ulcer. This evidence concerns the gene INS and peptic ulcer disease.