Sepsis-related mortality induced by endotoxemia is largely due to caspase-11 activation (Wang et al., 1998; Kayagaki et al., 2011; Kayagaki et al., 2013; Hagar et al., 2013; Kayagaki et al., 2015), which can cleave GSDMD to unleash active membrane pore-forming peptides. Here, GSDMD is linked to Sepsis.