observed that GCDCA activates the epidermal growth factor receptor, inducing hepatic stellate cell proliferation and liver fibrosis (Svegliati-Baroni et al., 2005), and this may be related to the activation of the epidermal growth factor receptor/MEK/ERK signaling pathway (Hohenester et al., 2020). Here, EGFR is linked to Hepatic fibrosis.