They can secrete IL-6 and IL-11, two cytokines that engage the same signaling cascade associated with the shared gp130 receptor subunit which not only suppress apoptosis and enhance proliferation of neoplastic IECs, but also promote migration of colon cancer cells and induce the epithelial–mesenchymal transition program in cancer cells and therefore enhance metastasis (184, 185). Here, IL6 is linked to cancer.