NFKB1 and rheumatoid arthritis: In our study, IFI44 was found to be a key crosstalk gene between RA and SAB, and IFI44 is also an IFN-I–negative regulator, which can give a decrease in antimicrobial inflammatory factors by negatively regulating the NF-κB pathway and can also inhibit STAT1 activation from blocking the production of IFN-I and ISGs (195).