Therefore, in this study, 1,25(OH)2VD3 was found to be a drug target through the enrichment pathway of the shared genes of RA and SAB, and 1,25(OH)2VD3 was found to be negatively associated with the expression of RA, COVID-19, SAB, IFI44, and the production and chemotactic activity of IFN-α in DCs from a new perspective. The gene discussed is SH3BP5; the disease is rheumatoid arthritis.