IFI44 and rheumatoid arthritis: In addition, it was reported for the first time in 2019 that IFI44 also functions as a negative regulator of the IFN signaling pathway and that IFN-α treatment induces high expression of IFI44 (195) and also triggers the development of RA (196), which corresponds to our study’s finding of high expression of IFI44 in patients with RA.