The high expression of IFI44 protein in patients with early RA facilitates further invasion of the organism by S. aureus, which is one of the reasons for S. aureus susceptibility, and the vicious cycle of immune imbalance in the organism resulting from the excessive IFN-I cascade response prompted by late RA and S. aureus stimulation is one of the reasons for the poor prognosis and high mortality. This evidence concerns the gene IFI44 and rheumatoid arthritis.