In this study, ClueGO was used to analyze the intersectional gene enrichment pathways of RA and SAB in IFN-I production, regulation of IFN-I production, regulation of IFN-I–mediated signaling pathway, IFN-I signaling pathway, IFN-α/β production, regulation IFN-α/β production, negative regulation of immune response, negative regulation of innate immune response, regulation of viral replication process, response to a virus, defense response to viruses, and cellular response to a virus, which is reflected in the IFN-I pathway. The gene discussed is SH3BP5; the disease is rheumatoid arthritis.