TRIM15 could regulate the Wnt/β-catenin signaling pathway and Keap1-Nrf2 pathway and mediate the ubiquitination of APOA1 and ERK to promote the development and progression of cancers such as non-small cell lung cancer, esophageal squamous cell carcinoma, and pancreatic cancer (35–37). This evidence concerns the gene KEAP1 and esophageal squamous cell carcinoma.