The data showed that the pyroptotic TC-1 tumor cell vaccine (GSDMD-NT-TC-1) significantly inhibited the growth of CT26 tumors (Figures 5G and S4) and protected 80% of the mice from forming a tumor (Figure 5H), indicating that the pyroptotic cell vaccine can elicit strong innate immunity and not just tumor antigen-specific systemic antitumor effects. The gene discussed is GSDMD; the disease is neoplasm.