NTAN1 and neoplasm: Since PNAd expression in I.P. tumors depends on effector CD8 T cells secreting LTα3 (31), and these therapies also enhanced the representation of T-cells in I.P. tumors (57), this suggests that immunotherapy-augmented PNAd expression on the tumor vasculature is driven by an increased number of intratumoral CD8 T cell effectors secreting LTα3.