N-3 PUFA increased the production of antioxidant enzymes and down-regulated mRNA expression of CD4+ T cell-associated genes, such as Cd80, Il6, Il10, Il18, Ccl5, Cxcr3, Tnfa, and Spp1, thereby reducing inflammatory response, oxidative stress, and autoimmune reactions in murine SLE models (11, 39–46). Here, IL10 is linked to systemic lupus erythematosus.