Calorie restriction has been shown to alleviate SLE manifestations such as proteinuria, glomerulonephritis, and deposition of immune complexes as well as to prolong the lifespan of lupus mouse models by down-regulating mRNA expression of genes encoding the proinflammatory mediators IFN-α, IL-10, IL-12, TNF-α, NF-κB, and polymeric immune globulin receptor (47–52). The gene discussed is TNF; the disease is systemic lupus erythematosus.