TNF and systemic lupus erythematosus: N-3 PUFA increased the production of antioxidant enzymes and down-regulated mRNA expression of CD4+ T cell-associated genes, such as Cd80, Il6, Il10, Il18, Ccl5, Cxcr3, Tnfa, and Spp1, thereby reducing inflammatory response, oxidative stress, and autoimmune reactions in murine SLE models (11, 39–46).