PTX3 and Sepsis: The concomitant upregulation of PTX3, CRP and pro-inflammatory cytokines (IL-6, IL-8, TNF-α) on one side, and of the anti-inflammatory molecules sIL-1R2, IL-10 and IL-1ra on the other side, further supports the coexistence of pro-inflammatory and immunosuppressive mechanisms throughout the host response to sepsis.