Aim of this study was to evaluate the prognostic value of molecules of the innate immune response, namely PTX3 and sIL-1R2, in association with a set of pro- and anti-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-10, IL-18, TNF-α and IL-1ra) and clinical parameters, in patients presenting at the Emergency Department with a suspicious or diagnosis of sepsis defined according to the Sepsis-3 criteria (65). This evidence concerns the gene TNF and Sepsis.