In addition, both molecules strongly correlated with SOFA score in sepsis and septic shock patients (PTX3: r=0.44, p<0.0001; sIL-1R2: r=0.35, p<0.0001), confirming data obtained in earlier studies (31, 44), as well as with PCT, CRP and clinical parameters of severity. The gene discussed is CRP; the disease is Sepsis.