CD8A and viral infectious disease: We found a higher frequency of naive (CD44loCD62Lhi) CD8 T cells and a lower frequency of the effector (CD44hiCD62Llo) CD8 T cells in the spleen of the Srsf1-cKO mice compared to WT, and the reverse scenario when we performed the same staining in MLN cells, with a lower frequency of naïve and higher frequency of effector CD8 T cells, both after LCMV infection (Figures 3D, E), reflecting an impaired activation/generation of effector T cells in response to an acute viral infection.