This is the first time that the effect of SRSF1 on CD8 T cells in the context of viral infection has been described, and our findings provide the basis for future work to determine which pathways are most relevant in this context, including those to define direct versus indirect binding targets of SRSF1 by RIP-seq or CLIP-seq types of RNA-protein binding studies to delineate which genes are direct targets and which are downstream and therefore indirect targets. This evidence concerns the gene CD8A and viral infectious disease.