The low number of CD8 cells was not accompanied by CD4 lymphopenia, as shown by the decreased CD8/CD4 ratio in the spleen (7.7) and MLN (2.6, n=3) of Srsf1-cKO mice compared to WT mice (1.3 and 0.96, p=0.0009 and p<0.0001, respectively) (Figures 3B, C). Here, SRSF1 is linked to lymphopenia.