LINC01116 can inhibit TPM1 transcription by increasing EZH2 to enhance the methylation of T, the PM1 promoter region, promote the proliferation and angiogenesis of CRC (37), or negatively regulate miR-9-5p to induce STMN1 expression, inhibit apoptosis, and promote the invasion and metastasis of CRC cells (38). The gene discussed is EZH2; the disease is colorectal carcinoma.