Lastly, we stratified these variables according to smoking habit, vitamin D levels and HLA DRB1*15:01: VCA IgG titers were increased in smoker female MS patients in comparison with non-smoker female MS patients (p=0.001); VCA IgG titers correlated with ARR in non-smoker MS patients (r=–0.371; p=0.002); finally, VCA IgG titers correlated with the age in non-smoker MS patients (r=0.364; p=0.003) and in non-carriers of HLA-DRB1*15:01 MS patients (r=0.220; p=0.002). This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.