Pathways depicting cholesterol, HDL and LDL metabolism (WP430, WP5109, WP4522, WP3601) are also among the top 10 pathways that have reduced activity in COVID-19 patients with significant reductions in APOA1, APOA2, APOC2, APOC3, APOB protein abundance. The gene discussed is APOC3; the disease is COVID-19.