The post-squalene cholesterol biosynthesis and estrogen receptor (WP4804, WP2881) pathways have the most increase in activity with all proteins detected more abundant in COVID-19; the next most active pathways in the thyroid are omega-3/6 fatty acid synthesis pathways (WP4723) and mitochondria fatty acid synthesis pathway (WP4317) with all proteins detected more abundant in COVID-19. Here, ESR1 is linked to COVID-19.