We found many pathways from the COVID-19 Disease Map and the COVID-19 portal in WikiPathways such as the MINERVA Virus replication cycle, SARS-CoV-2 and COVID-19 pathway (WP4846) and nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell (WP5027) among the most active pathways in COVID-19 patients. The gene discussed is SH2D3A; the disease is COVID-19.