Feeding 2-Fucosyllactose to mice with colitis can decrease IL-1β and IL-6 expression, increase TGF-β and occludin expression and propionate concentration, accompanied by the expansion of Ruminococcus, and the most important thing is to effectively alleviate inflammation (136).Clinical trials on the application of prebiotics have been established to investigate its safety and feasibility in the treatment of IMC(NCT04552418, see Table 2 for details). The gene discussed is IL1B; the disease is colitis.