Ultimately, 22 genes were selected as the characteristic genes of NSCLC immunotherapy response, including CLEC19A, SEC14L3, SLC27A6, APCDD1L, FGF16, CBLN2, SLC24A2, CEACAM8, KRTAP2-3, GBX1, ZDHHC22, CASR, UNC80, C1QL4, NKX3-2, IGFL3, GUCA1A, NETO1, SP7, UGT2B15, AC020922.1 and DLX2 (Figure 1E). The gene discussed is CBLN2; the disease is non-small cell lung carcinoma.