The top 10 KEGG Human pathways include bladder cancer, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, p53 signaling pathway, colorectal cancer, prostate cancer, Chagas disease, NF-kappa B signaling pathway, and base excision repair. The gene discussed is HIF1A; the disease is Chagas disease.