Additionally, the loss of TET2, which encodes ten-eleven translocation (TET) DNA dioxygenase, is correlated with reduced Th1-type chemokine generation, including CXCL9, CXCL10, and CXCL11, with the downregulated expression of PD-L1 and impaired T-cell attraction to tumor tissues, leading to immune escape and resistance to anti-PD-L1 therapy in the B16-OVA melanoma tumor model (73). The gene discussed is CD274; the disease is melanoma.