Moreover, several studies have shown that aCL occurred frequently during viral infections, particularly in HIV (49,7%), hepatitis B virus (HBV) (24%), and hepatitis C virus (HCV) (20%), while anti-B2GPI very rarely detected; aPL during the course of infections did not generally associate with thrombosis or other manifestations of APS (15). This evidence concerns the gene APOH and autoimmune polyendocrinopathy.