In particular, we observed 11 cases of preeclampsia, of which 4 in aPL positive patients (1 in a patient with isolated LA positivity, and 3 in the double positivity group,2 with IgG aCL and IgG aB2GPI, 1 with LA and IgG aB2GPI); 12 cases of postpartum hemorrhage, of which one occurred in a patient with isolated positive IgM aB2GPI and one in a patient with IgG aCL and IgG aB2GPI; one case of HELLP syndrome in a double positive patient (IgG aCL and IgG aB2GPI). The gene discussed is CD40LG; the disease is preeclampsia.