Notably, inhibition of miR-21 expression significantly decreased the proliferation of C-C Motif Chemokine Receptor 6 (CCR6+) Tregs, altered the recruitment of CCR6+ Tregs into the tumor site and effectively endowed CD8+ T cells with an anticancer function by altering the PTEN/Akt axis (128) (Figure 3). The gene discussed is PTEN; the disease is neoplasm.