Recently, a meta-analysis of the role of miRNAs in gene expression regulation identified cancer-associated signatures that underline the high expression of miR-17-5p, which extensively regulates the expression of TS proteins such as Phosphatase And Tensin Homolog (PTEN), FAT Atypical Cadherin 4 (FAT4) and cyclin-dependent kinase 12 (CDK12), demonstrating miRNA-mediated gene expression regulation across tumor types and revealing a major alternative method of gene suppression in addition to mutation, methylation and copy number changes (16). The gene discussed is FAT4; the disease is cancer.