CXCR4 and colorectal carcinoma: However, several upregulated oncomiRs, including miR-25-3p, miR-130b-3p, and miR-425-5p, encased in the exosome produced by CRC cells were shown to be absorbed by macrophages, inducing activation of the CXCL12/CXCR4 axis by promoting liver metastasis in CRC.