Functional follicular helper T cells (Tfh) oriented by T-helper 1 (Th1) cells can promote humoral and cytotoxic immune responses in human breast cancer (43), and the presence of CXCL13-producing Tfh cells in tertiary lymphoid structures (TLS) of breast tumors robustly predicts positive clinical outcomes (44). The gene discussed is CXCL13; the disease is breast cancer.