Different patterns of CNV were observed in all BC patients, among which GSDMC, CHMP6, GSDMD, NLRP3, and GSDMB exhibited the highest incidence of increased CNV, while CASP9, IL18, TIRAP, GPX4, and ELANE represented PRGs with the most frequent decrease in CNV. The gene discussed is GSDMB; the disease is breast cancer.